![]() ![]() ![]() Our goal was to create hNMJs on a specific pattern of electrodes to stimulate pre-synaptic axons and record post-synaptic muscle activity. ![]() Here, we combined microfluidics with two techniques: soft lithography and custom microelectrodes array (MEA). Such devices have already been developed to study in vitro neuronal circuitry. To investigate this cell network, microfluidic platforms are useful to grow different cell types in isolated compartments. In order to better understand human neuromuscular junction (hNMJ) functionality, it is important to develop on-a-chip devices with human cells. In the neuromuscular system, signal transmission from motor neurons (MNs) to innervated muscle fibers is crucial for their synaptic function, viability, and maintenance. ![]()
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